Pemetrexed

Anti-metabolite

MECHANISM OF ACTION

Inhibits folate and DNA synthesis

MECHANISM OF KIDNEY INJURY

CLINICAL KIDNEY SYNDROME

neutropenia, stomatisis, and macrocytic anemia

CARDIOVASCULAR ADVERSE EFFECTS

Sinus arrhythmia - 1 case report PMID: 36281405.

LYTE ABNORMALITIES

RISK FACTORS

MITIGATION STRATEGIES

SUGGESTIONS

NOTES/COMMENTS

eGFR < 60 ml/min, not recommended

PHARMACOKINETICS

Molecular Weight

427

Volume of Distribution

16.1L

Plasma Protein Binding

70-80%

Metabolism

Bioavailability

Half-life elimination

3.5Hrs in normal renal function

Time to peak

Excretion

Urine, 70-90%

Dialyzable?

REF:

PATHOLOGY SLIDES:

ENTRY UPDATES:

Raad Chowdhury

United States

Sep 25, 2022

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