PARTNERS WITH
Capecitabine
Anti-metabolite
MECHANISM OF ACTION
Prodrug of 5FU. 5-FU is an antimetabolite interfering with DNA and RNA synthesis.
MECHANISM OF KIDNEY INJURY
Not commonly associated with AKI may cause dehydration and pre-renal AKI
CLINICAL KIDNEY SYNDROME
Cardio and hepato toxicticity, hand foot syndrome
myelosuppresion, hyperpigmentation, nail bnading, ocular toxicity, MI
CARDIOVASCULAR ADVERSE EFFECTS
ACS, arrhythmia, cardiomyopathy, CHF, and edema
LYTE ABNORMALITIES
RISK FACTORS
MITIGATION STRATEGIES
SUGGESTIONS
NOTES/COMMENTS
eGFR > 60 ml/min , no adjustment although toxicity seen up to eGFR 90 ml/min
eGFR 30-59 ml/min, 75% of usual dose
eGFR < 30 ml/min, avoid use
PHARMACOKINETICS
Molecular Weight
359
Volume of Distribution
Plasma Protein Binding
<60%
Metabolism
Bioavailability
Half-life elimination
45 mins
Time to peak
Excretion
urine 96%
Dialyzable?
Generally, use is not recommended. Case reports reported possible tolerability (jhaveri 2012, sasaki 2019)
REF:
PATHOLOGY SLIDES:
ENTRY UPDATES:
Raad Chowdhury
United States
Sep 25, 2022