Bosutinib

Tyrosine kinase inhibitors

MECHANISM OF ACTION

Cellular TKI that inhibits BCR-ABL

MECHANISM OF KIDNEY INJURY

No reported true AKI

CLINICAL KIDNEY SYNDROME

unclear if true AKI occurs.

CARDIOVASCULAR ADVERSE EFFECTS

HTN, chest pain, edema , heart failure, pericardial effusion, QT prolonagtion , pericarditis

LYTE ABNORMALITIES

Hypophosphatemia

RISK FACTORS

n/a

MITIGATION STRATEGIES

n/a

SUGGESTIONS

Check UA with urine culture, unclear. replace phos. check electrolytes

NOTES/COMMENTS

PHARMACOKINETICS

Molecular Weight

Volume of Distribution

Plasma Protein Binding

Metabolism

Bioavailability

Half-life elimination

Time to peak

Excretion

Dialyzable?

Unknown

REF:

PMID: 29318210
https://www.lumc.nl/sub/4010/att/1683422/1896506

PATHOLOGY SLIDES:

ENTRY UPDATES:

Raad Chowdhury

MN/USA

Sep 25, 2022

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